Since 1967, 29 male/female duets have topped the Billboard Hot 100 singles chart, here’s the list.
| Artists | Title | Year |
| Nancy Sinatra & Frank Sinatra | Somethin’ Stupid | 1967 |
| Paul & Linda McCartney | Uncle Albert/Admiral Halsey | 1971 |
| Paul Anka & Odia Coates | (You’re) Having My Baby | 1971 |
| Elton John & Kiki Dee | Don’t Go Breaking My Heart | 1976 |
| Marilyn McCoo & Billy Davis Jr | You Don’t Have to Be a Star | 1977 |
| Johnny Mathis & Deniece Williams | Too Much Too Little Too Late | 1978 |
| John Travolta & Olivia Newton-John | You’re the One That I Want | 1978 |
| Barbra & Neil | You Don’t Bring Me Flowers | 1978 |
| Diana Ross & Lionel Richie | Endless Love | 1981 |
| Joe Cocker & Jennifer Warnes | Up Where We Belong | 1982 |
| Patti Austin & James Ingram | Baby, Come to Me | 1983 |
| Kenny Rogers & Dolly Parton | Islands in the Stream | 1983 |
| Phil Collins & Marilyn Martin | Separate Lives | 1985 |
| Patti LaBelle & Michael McDonald | On My Own | 1986 |
| Peter Cetera & Amy Grant | The Next Time I Fall | 1986 |
| Aretha Franklin & George Michael | I Knew You Were Waiting (For Me) | 1987 |
| Michael Jackson & Siedah Garrett | I Just Can’t Stop Loving You | 1987 |
| Bill Medley & Jennifer Warnes | (I’ve Had) The Time of My Life | 1987 |
| Peabo Bryson & Regina Belle | A Whole New World | 1993 |
| Puff Daddy & Faith Evans feat 112 | I’ll Be Missing You | 1997 |
| R. Kelly & Celine Dion | I’m Your Angel | 1998 |
| Usher & Alicia Keys | My Boo | 2004 |
| Jay-Z & Alicia Keys | Empire State of Mind | 2009 |
| Ed Sheeran & Beyoncé | Perfect | 2017 |
| Lady Gaga & Bradley Cooper | Shallow | 2019 |
| Shawn Mendes & Camila Cabello | Señorita | 2019 |
| Ariana Grande & Justin Bieber | Stuck With U | 2020 |
| 6ix9ine & Nicki Minaj | Trollz | 2020 |
| The Weeknd & Ariana Grande | Save Your Tears | 2021 |